A study of genetic association between manic‐depressive illness and a highly polymorphic marker from the GABRβ‐1 gene
R Puertollano, G Visedo, C Zapata… - American journal of …, 1997 - Wiley Online Library
R Puertollano, G Visedo, C Zapata, J Fernández‐Piqueras
American journal of medical genetics, 1997•Wiley Online LibraryWe report on an association study between a tetranucleotide repeat polymorphism in the
GABRβ1 gene and manic‐depressive illness in a Spanish population. This gene may be an
important candidate for bipolar affective disorders since severe GABergic alterations have
been described in patients. Although our results do not reveal a clear evidence for
association between manic‐depressive illness and GABRβ1, we have found significant
differences between patients and controls in the female subpopulation. Am. J. Med. Genet …
GABRβ1 gene and manic‐depressive illness in a Spanish population. This gene may be an
important candidate for bipolar affective disorders since severe GABergic alterations have
been described in patients. Although our results do not reveal a clear evidence for
association between manic‐depressive illness and GABRβ1, we have found significant
differences between patients and controls in the female subpopulation. Am. J. Med. Genet …
Abstract
We report on an association study between a tetranucleotide repeat polymorphism in the GABRβ1 gene and manic‐depressive illness in a Spanish population. This gene may be an important candidate for bipolar affective disorders since severe GABergic alterations have been described in patients. Although our results do not reveal a clear evidence for association between manic‐depressive illness and GABRβ1, we have found significant differences between patients and controls in the female subpopulation. Am. J. Med. Genet. 74:342–344, 1997. © 1997 Wiley‐Liss, Inc.
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